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Introduction to metabolomics (Q2 2015)

Name of course:

Introduction to metabolomics



ECTS credits:
2


Course parameters:

Language: English

Level of course: PhD course (with participation of a few master students)

Time of year: November 2015 (Q2)

Hours:

2 days of lectures and exercises (16 h)

½ day of working with the students own data (4 h)

Preparation by reading book chapters, articles and preparing data for analysis (20 h)

Writing report (20 h)

Capacity limits: max 25, min 10. PhD students have highest priority

Course fee: 500 DKK for PhD and master students (covers coffee/bread in the morning and afternoon), 3000 DKK for others. A discount is available if the PhD course ‘Introduction to multivariate data analysis (chemometrics)’ is also followed.


Objectives of the course:

The purpose of the course is to give an up-to-date introduction to the basic methods in metabolomics. The course will cover nuclear magnetic resonance (NMR) spectroscopy and liquid chromatography mass spectrometry (LC-MS) methodologies used in metabolomics.



Learning outcomes and competences:

At the end of the course, the student should be able to:

  • Arrange the place of metabolomics in context of genomics, proteomics, *omics
  • Compare and contrast the methods for a metabolomics study considering the benefits and the pitfalls of the methods
  • Describe and explain how to prepare samples from different foods and bio-fluids for metabolomic analyses
  • Evaluate and apply the appropriate experimental design in a metabolomics study
  • Explain the principles of metabolite detection and identification in LC-MS and NMR
  • Outline applications of metabolomics to your field of research
  • Apply multivariate data analysis methods relevant for metabolomic data
  • Critically evaluate metabolomic data described in scientific literature and describe your own results in a scientific way

Compulsory programme:

Attendance for a minimum of 80% of the theoretical and practical lessons is required to obtain the course diploma. Approved report.

 

Course contents:

Metabolism is the set of chemical reactions that occur in living organisms in order to maintain life and metabolites is the end products of these chemical reactions. Metabolomics is the systematic study of metabolite profiles in any biological sample and tissue. Set in a systems biology context, the metabolomics is the most recent member of the omics-family and it is complementary to genomics and proteomics.

The course gives an introduction to the use of metabolomics and its methods. The objectives are to give participants knowledge of advanced NMR and MS techniques, including hands-on experience with processing, analysis and identification of metabolites in such data.

Theoretical and practical aspects of these methods, including sample preparation, data acquisition, processing and further analysis will be discussed. The course will cover NMR- and MS-based metabolomics applied to various types of samples – meat and vegetable extracts, cells, milk, urine, blood, and feces – will be used as examples.

 

Prerequisites:

Enrolled in a science based PhD programme. Master students can participate as a part their master project in agreement with the supervisor.

 

 

Name of lecturers:

Post doc Ulrik Kræmer Sundekilde, Department of Food Science, Aarhus University, Denmark (responsible)

Post doc Christian Clement Yde, Department of Food Science, Aarhus University, Denmark

 

 

Type of course/teaching methods:

Lectures and exercises



Literature:

Selected chapters and papers will be announced later. During the course SIMCA-P+ will be used for data analysis. You need to install the software at your computer. A trial version will be made available to students on blackboard. You will receive a folder with information and printouts from the lectures at the beginning of the course.



Course homepage:

None



Course assessment:

Written report, presentation and discussion of results considering the learning outcomes. Passed/not passed.



Provider:

Department of Food Science



Special comments on this course:

The course is organized in combination with the PhD-course ‘Introduction to multivariate data analysis (chemometrics)’ and it is encouraged to follow both courses, although the courses can be taken individually if necessary. There will be a discount if you follow both courses. The fee covers coffee and bread in the morning and afternoon.



Time:

Metabolomics only:

Thursday, 12 November: Lectures

Friday, 13 November: Lectures

Wednesday, 18 November: Data preparation

Monday-Friday, 23-27 November: Report work

Monday, 30 November at noon: Deadline for handing in report

Friday, 2 December: Notice of assessment


Chemometrics only:

Monday, 16 November: Lectures

Tuesday, 17 November: Lectures

Thursday, 19 November: Lectures

Friday, 20 November: Working with own data

Monday-Friday, 23-27 November: Report work

Monday, 30 November at noon: Deadline for handing in report

Thursday, 3 December: Examination

 

Metabolomics and Chemometrics

Thursday, 12 November: Lectures metabolomics

Friday, 13 November: Lectures metabolomics

Monday, 16 November: Lectures chemometrics

Tuesday, 17 November: Lectures chemometrics

Wednesday, 18 November: Data preparation metabolomics

Thursday, 19 November: Lectures chemometrics

Friday, 20 November: Working with own data chemometrics

 

Monday-Friday, 23-27 November: Report work

Monday, 30 November at noon: Deadline for handing in report

Thursday, 3 December: Examination chemometrics



Place:

Aarhus



Registration:

Deadline for registration is 1 October 2015. Information regarding admission will be sent out no later than two workdays after registration. Remember to also sign up for Chemometrics if you want to participate in both courses.

For registration (Metabolomics only or both courses): auws.au.dk/Metabolomics_2015

If you have any questions, please contact Ulrik Sundekilde, e-mail: uksundekilde@food.au.dk or Christian Clement Yde, e-mail yde@food.au.dk.

 

The course fee is:

Metabolomics only:

PhD students and master students enrolled at Danish Universities and AU-FOOD staff: 500 DKK

Others: 3000 DKK

 

Chemometrics only:

PhD students and master students enrolled at Danish Universities and AU-FOOD staff: 1500 DKK

Others: 5000 DKK

 

Metabolomics and Chemometrics

PhD students and master students enrolled at Danish Universities and AU-FOOD staff: 1750 DKK

Others: 7500 DKK

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Revised 16.05.2017