Armed antibody with drug or toxin: a promising weapon to win the “war against cancer”

PhD defence, Friday 25 November 2016. Tianqiang Liu.

2016.11.25 | Steffi Hjerrild Iversen

Tianqiang Liu

During his PhD studies, Tianqiang Liu researched antibody that linked with drug or toxin for cancer therapeutics. Antibody, a Y-shaped glycoprotein, has been widely used for cancer treatment in clinical medicine. Modification of antibody with chemotherapeutic drugs or toxins has attracted great attention for developing new therapeutics, due to the specificity of antibody to cancer cells and high toxicity of conjugated payloads. The focus of Tianqiang Liu’s PhD project was to modify antibody site-selectively and link them with anti-cancer drug (doxorubicin) or protein toxin with a creative design. Tianqiang Liu used DNA as the linker to arm antibody with drug or toxin and found an enhanced improvement for killing cancer cells in vitro.

The new research findings contribute to the general understanding of versatile features of DNA both as template for site-selective antibody conjugation and linker to connect antibody with drugs. The application of DNA provides a new strategy for researchers to design antibody-drug conjugates and offers a high degree of modularity where a variety of two or more protein conjugates can be applied on a joint template.

The PhD degree was completed at the Interdisciplinary Nanoscience Center (iNANO), Science and Technology, Aarhus University.

This résumé was prepared by the PhD student.

Time: Friday 25 November 2016 at 14.15
Place: Building 1523, room 318, the Lecture Theatre, Department of Physics and Astronomy, Aarhus University, 8000 Aarhus C.
Title of dissertation: DNA templated antibody conjugation for targeted drug delivery to cancer cells
Contact information: Tianqiang Liu, e-mail: tliu@inano.au.dk, tel.: +45 5022 5640
Members of the assessment committee:
Associate Professor Bjørn Högberg, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Professor Jesper Wengel, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark
Associate Professor Alexander N. Zelikin (chair), iNANO and Department of Chemistry, Aarhus University
Main supervisor:
Professor Kurt V. Gothelf, iNANO and Department of Chemistry, Aarhus University
Language: The PhD dissertation will be defended in English

The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1520, rooms 128-134, 8000 Aarhus C.

PhD defence
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Revised 08.12.2017