Building Bones – Theranostics and Cellular Signals in Bone Tissue Engineering

PhD defence, Wednesday 17 January 2018, Clare (Chi-Chih) Chang.

2018.01.17 | Trine Berndt Turtiainen Scheelke

Clare (Chi-Chih) Chang

During her PhD studies, Clare (Chi-Chih) Chang researched molecular cues and cell labeling in bone formation. Stem cells can form bone cells when given the correct signals. When these signals are combined with a scaffold, an engineered bone graft mimic is produced. Clare (Chi-Chih) Chang studied how microRNAs direct the formation of bone cells both within and outside the cells. A new contrast agent was also developed to monitor the cells during cell therapy. These findings contribute to future methods for the use of RNAs in bone tissue engineering, and new methods for cell monitoring in cell therapies.

The PhD degree was completed at the Interdisciplinary Nanoscience Center (iNANO), Science and Technology, Aarhus University.

This résumé was prepared by the PhD student.

Time: Wednesday, 17 January 2018 at 13.15
Place: Building 1593, room 012, the Lecture Theatre, iNANO House, Gustav Wieds Vej 14, Aarhus University, 8000 Aarhus C.

Title of dissertation:
 Bone enhancing molecular cues and cell monitoring in tissue engineering
Contact information: Clare Chang, e-mail:, tel.: +45 5267 3117
Members of the assessment committee:
A2 Professor, PhD, Johannes Grillari, Christian Doppler Laboratory on Biotechnology of Skin Aging, Department of Biotechnology, BOKU - University of Natural Resources and Life Sciences, Vienna, Austria
Professor Sakari Kauppinen, Department of Clinical Medicine, Faculty of Medicine, Aalborg University Copenhagen
Professor Daniel Otzen (chair), iNANO and Department of Molecular Biology and Genetics, Aarhus University
Main supervisor:
Professor Jørgen Kjems, iNANO and Department of Molecular Biology and Genetics, Aarhus University
Language: The PhD dissertation will be defended in English

The defence is public.

The dissertation is available for reading at the Graduate School of Science and Technology/GSST,
Ny Munkegade 120, building 1520, rooms 128-134, 8000 Aarhus C.

PhD defence
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Revised 17.05.2018