Combatting bacterial biofilm infections with tailored nanomedicine

PhD defence, Tuesday, 16 October 2018. Pernille Ommen Andersen.

2018.10.16 | Olivia Elsebeth Belling-Nami

Pernille Ommen Andersen.

Snapshot of bacteria (blue) in a biofilm recognized and surrounded by targeted nanovesicles (green). During her PhD project, Pernille Ommen Andersen identified a new ligand that could mediate binding of the antibiotic-carrying nanovesicles to bacteria in a biofilm.

During her PhD studies, Pernille Ommen Andersen researched a new strategy to treat infections caused by bacterial biofilms.
As bacteria stick to a surface and form a biofilm, e.g. on a medical implant, the bacteria become surrounded by a protective substance and enter a physiological state that increases their tolerance to antibiotics dramatically. Infections caused by bacterial biofilms are therefore often untreatable with conventional antibiotic therapy - the antibiotics can simply not be dosed in concentration sufficient to kill the bacteria in the biofilm without also causing detrimental side effects.
As a potential solution to this challenge, a tailored formulation of nano-encapsulated antibiotics capable of finding, accumulating and releasing its content inside the biofilm was developed and tested.

The PhD degree was completed at the Interdisciplinary Nanoscience Center (iNANO), Science and Technology, Aarhus University.

This résumé was prepared by the PhD student.

Time: Tuesday, 16 October 2018 at 13.15
Place: Building 1593, room 012, the Lecture Theatre, iNANO House, Gustav Wieds Vej 14, Aarhus University, 8000 Aarhus C.
Title of PhD thesis: Development of a targeted drug delivery system for Staphylococcus aureus biofilm infections
Contact information: Pernille Ommen Andersen, e-mail: pernille.ommen@inano.au.dk, tel.: +45 2071 2981

 

Members of the assessment committee:
Professor Hanne Mørck Nielsen, Department of Pharmacy, University of Copenhagen
Professor Henny van der Mei, Faculty of Medical Sciences, University of Groningen, the Netherlands
Senior Scientist Morten Foss (chair), iNANO, Aarhus University
Main supervisor:
Associate Professor Rikke L. Meyer, iNANO and Deparment of Bioscience, Aarhus University
Co-supervisor:
Professor Jørgen Kjems, iNANO and Department of Molecular Biology and Genetics, Aarhus University
Language: The PhD dissertation will be defended in English

The defence is public.
The PhD thesis is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, buildings 1520 and 1521, 8000 Aarhus C.

PhD defence
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Olivia Elsebeth Belling-Nami

Revised 19.10.2018