Combining palladium and carbon monoxide – providing compounds containing carbonyls

PhD defence, Friday, 24 February 2017. Hongfei Yin

2017.02.24 | Steffi Hjerrild Iversen

Hongfei Yin

During his PhD studies, Hongfei Yin put his efforts into synthesizing carbonyl-containing compounds by using carbon monoxide and palladium catalysts. Compounds bearing carbonyl groups are frequently found in pharmaceuticals and natural products. Besides, carbonyls are very important building blocks in organic synthesis. Therefore, the development of synthesizing compounds carrying carbonyl groups has drawn tremendous attention. Palladium has been considered as a suitable mediator to bridge two organic moieties together (usually one of them is an aryl halide and the other one is a nucleophile) and insert CO between them. Hongfei Yin used the COware system, which allows generating and consuming carbon monoxide safely in the same sealed setup to search for optimal conditions for several Pd-catalyzed carbonylative reactions.

The new research findings contribute to expanding the scope of Pd-catalyzed carbonylative reactions, providing mild and convenient methods to obtain acyl carbamates, 1,4-diketones and 1-aryl-2-(pyridin-2-yl)ethan-1-ones. Furthermore, 13C-labeled compounds were achieved by using the methodology presented in his studies.

The PhD degree was completed at the Interdisciplinary Nanoscience Center (iNANO), Science and Technology, Aarhus University.

This résumé was prepared by the PhD student.

Time: Friday, 24 February 2017 at 10.15
ce: Building 1514, room 213, Lecture Theatre I, Department of Chemistry, Langelandsgade 140, Aarhus University, 8000 Aarhus C.
Title of dissertation:
New developments in carbonylative coupling reactions via palladium catalysis
Contact information:
Hongfei Yin, e-mail:, tel.: +45 8715 6759, mobile number: +45 5278 6856
Members of the assessment committee:

Professor Michael Willis, Department of Chemistry, University of Oxford, Oxford, Great Britain
Professor Mogens Brøndsted Nielsen, Department of Chemistry, University of Copenhagen
Professor Kurt V. Gothelf (chair), iNANO and Department of Chemistry, Aarhus University
Main supervisor:

Professor Troels Skrydstrup, iNANO and Department of Chemistry, Aarhus University
The PhD dissertation will be defended in English

The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1520, rooms 128-134, 8000 Aarhus C.

PhD defence
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Revised 23.02.2018