Diverse RNA classes use common maturation pathways

PhD defense, Tuesday 10 April 2018 Ewa Molska

2018.04.10 | Liselotte K Heller

Ewa Molska

During her studies, Ewa Molska researched the processing and transcription termination pathways of RNAs. In eukaryotic cells RNA polymerases transcribe diverse classes of genes from a DNA template. The produced RNAs need to be targeted to their appropriate cognate biochemical maturation pathways. Specific protein complexes are involved in processing of different groups of RNAs to ensure their functionality. Ewa used a specialised next generation sequencing approach, to investigate roles of three machineries involved in the last steps of RNA processing and transcription termination with a special focus on a  variable class of RNAs called the long non-coding RNAs.

The new findings of her research contribute to RNA classification based on biochemical properties, which enable a better understanding about the biogenesis and possible functionality of transcripts.

The PhD degree was completed at the Department of Molecular Biology and Genetics, Science and Technology, Aarhus University.

This résumé was prepared by the PhD student.

Time: Tuesday 10 April 2018, 14:00
Place: Lecture Theatre D2,  Building 1531, room 119, Department of Mathematics, Aarhus University, Ny Munkegade 118, 8000 Aarhus C.
Title of PhD thesis: Global investigation of RNA 3'end processing and transcription termination pathways
Contact information: Ewa Molska, e-mail: molska@mbg.au.dk, tel.: +45 50151019
Members of the assessment committee:
Associate Professor Peter Brodersen, Department of Bioinformatik og RNA Biologi, University of Copenhagen
Associate Professor Andre Furger, Department of Biochemistry, University of Oxford
Associate Professor Ernst-Martin Füchtbauer, Department of Molecular Biology and Genetics , Aarhus University (chair)
Main supervisor:
Professor Torben Heick Jensen, Department of Molecular Biology and Genetics, Aarhus University
Language: The PhD dissertation will be defended in English


The defence is public.
The PhD thesis is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1520, rooms 128-134, 8000 Aarhus C.

PhD defence
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Revised 16.04.2018