Dynamics of Telomeric DNA and Identification of G-quadruplex Structures

PhD defense, Friday 19 January 2018, Siri Søndergaard.

2018.01.19 | Trine Berndt Turtiainen Scheelke

Siri Søndergaard

During her PhD studies, Siri Søndergaard investigated the dynamics of a specific type of secondary DNA fold found at the end of telomeres. The presence of these folds, G-quadruplexes, are relevant for the development of novel anti-cancer therapeutics. Siri Søndergaard studied how information from computational modeling can be used to develop a method for distinguishing between different naturally occurring G-quadruplex structures. The new research findings contribute to the understanding of G-quadruplex systems and emphasize the benefits of combining in silico and in vitro studies.

The PhD degree was completed at the Interdisciplinary Nanoscience Center (iNANO), Science and Technology, Aarhus University.

This résumé was prepared by the PhD student.

Time: Friday, 19 January 2018 at 9.15
Place: Building 1514, room 213, Lecture Theatre I, Department of Chemistry, Langelandsgade 140, Aarhus Universit, 8000 Aarhus C.
Title of dissertation: Computational modeling of G-quadruplex systems in relation to FRET
Contact information: Siri Søndergaard, e-mail: ss@inano.au.dk, tel.: +45 2623 4834
Members of the assessment committee:
Associate Professor Giovanni Bussi, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy
Professor Kresten Lindorff-Larsen, Department of Biology, University of Copenhagen
Professor Jan Skov Pedersen (chair), iNANO and Department of Chemistry, Aarhus University
Main supervisor:
Professor Birgit Schiøtt, iNANO and Department of Chemistry, Aarhus University
Associate Professor Victoria Birkedal, iNANO and Department of Chemistry, Aarhus University
Language: The PhD dissertation will be defended in English

The defense is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST,
Ny Munkegade 120, building 1520, rooms 128-134, 8000 Aarhus C.

PhD defence
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Revised 25.04.2018