Enantioselective Organocatalytic Approaches to Cyclic Natural Product Scaffolds

PhD Defence, Monday 22 January 2018, Bruno Paz.

2018.01.22 | Trine Berndt Turtiainen Scheelke

Bruno Paz

During his studies, Bruno Paz focused on the application of asymmetric organocatalysis to the synthesis of valuable scaffolds. Different Enantioselective organocatalytic cyclizations were developed by using four types of unsaturated aldehydes. The principle of vinylogy applied to HOMO-raising and LUMO-lowering aminocatalytic strategies facilitated the enantioselective formation of carbocycles and chromanes. A double cyclization forming chiral benzofused acetals was promoted by iminium-ion catalysis followed by an intramolecular acetalization cascade. A double cyclization forming chiral tetrahydrofuro[b]benzofurans was facilitated by using Brønsted base and NHC-catalysis in a one-pot strategy. These findings extended the aplications of organocatalysis and contributed to the understanding of organocatalytic mechanisms.

The PhD degree was completed at the Chemistry Department, Science and Technology, Aarhus University.

This résumé was prepared by the PhD student.

Time: Monday 22 January 2018 at 13:15
Place: Building 1523, room 318, Physics Auditorium, Department of Physics and Astronomy, Ny Munkegade 120, Aarhus University, 8000 Aarhus C.
Title of dissertation: Enantioselective Organocatalytic Approaches to Cyclic Natural Product Scaffolds
Contact information: Bruno Paz, e-mail: brunompaz@chem.au.dk.
Members of the assessment committee:

Professor Jieping Zhu, Institut des sciences et ingénierie chimiques (ISIC), École Polytechnique Fédérale de Lausanne (EPFL), Switzerland.
Professor Mogens Brøndsted Nielsen, Department of Chemistry, University of Copenhagen.
Associate Professor Jacob Overgaard (chair), Department of Chemistry, Aarhus University.
Main supervisor:
Professor Karl Anker Jørgensen, Chemistry Department, Aarhus University
Language: The PhD dissertation will be defended in English

The defence is public.

The dissertation is available for reading at the Graduate School of Science and Technology/GSST,
Ny Munkegade 120, building 1520, rooms 128-134, 8000 Aarhus C.

PhD defence
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Revised 25.04.2018