Expanding the chemical toolbox in DNA-directed chemistry

PhD defence, Friday 5 May 2017. Ana Carolina Suárez

2017.05.05 | Steffi Hjerrild Iversen

Ana Carolina Machado Suárez

During her PhD studies within the field of DNA nanotechnology, Ana Carolina Suárez has investigated linkers for DNA directed synthesis of libraries of small molecules. To prepare such libraries, bifunctional linkers are required to attach chemical compounds to DNA oligonucleotides and to transfer compounds from one DNA strand to another. However, only few linkers are compatible with DNA directed synthesis. Ana Carolina Suárez employed the yoctoReactor technology, a method to build DNA encoded combinatorial molecular libraries, to develop a photocleavable linker and a linker that features a carboxylic acid.

The new research findings contribute to expand the diversity of libraries and to increase the linker chemistry in DNA-directed synthesis.

The PhD degree was completed at the Interdisciplinary Nanoscience Center (iNANO), Science and Technology, Aarhus University.

The résumé was prepared by the PhD student.



Time:
Friday, May 5 2017 at 10.15
Place:
Building 1523, room 318, the Lecture Theatre, Department of Physics and Astronomy, Ny Munkegade 120, Aarhus University, 8000 Aarhus C
Title of dissertation:
Development of new linker strategies for the yoctoReactor technology
Contact information:
Ana Carolina Suárez, email: anas@inano.au.dk, tel: +45 9199 2016
Members of the assessment committee:

Professor Andriy Mokhir, Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität, Erlangen-Nürnberg, Germany
Professor Poul Nielsen, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark
Professor Troels Skrydstrup (chair), iNANO and Department of Chemistry, Aarhus University
Main supervisor:

Professor Kurt V. Gothelf, iNANO and Department of Chemistry, Aarhus University
Co-supervisor:

Associate Director, PhD Lars Kolster Petersen, Vipergen, Copenhagen
Language:
The PhD dissertation will be defended in English

The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1520, rooms 128-134, 8000 Aarhus C.

PhD defence
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Revised 25.09.2017