Exploring the Limits of Chemically Induced Control – Activatable Reagents and Light Dependent Control of Proteins

PhD defence, Friday 5 May 2017. Julie Brender Trads

2017.05.05 | Steffi Hjerrild Iversen

Julie Brender Trads

During her PhD studies, Julie Brender Trads has worked with development of new acyl transfer reagents. An activatable acyl transfer reagent relying on oxidative aromatization was developed and used in the synthesis of amides, esters and thioesters.

Julie Brender Trads has also synthesized photochromic ligands for use in photopharmacology and investigated the compounds' ability to induce light dependent control of GIRK channels, farnesoid X receptors (FXR) and hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.

The PhD degree was completed at the Interdisciplinary Nanoscience Center (iNANO), Science and Technology, Aarhus University.

This résumé was prepared by the PhD student.

Time: Friday 5 May 2017 at 13.15
Building 1514, room 213, Lecture Theatre I, Department of Chemistry, Langelandsgade 140, Aarhus University, 8000 Aarhus C.
Title of dissertation:
Synthesis and Investigation of New Acyl Transfer Reagents and Photochromic Ligands
Contact information:
Julie Brender Trads, e-mail: jtrads@chem.au.dk
Members of the assessment committee:

Professor, Dr. Andriy Mokhir, Department Chemie und Pharmazie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany
Professor Poul Nielsen, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark
Professor Duncan Sutherland (chair), iNANO, Aarhus University.
Main supervisor:

Professor Kurt V. Gothelf, iNANO and Department of Chemistry, Aarhus University
The PhD dissertation will be defended in English

The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1520, rooms 128-134, 8000 Aarhus C.

PhD defence
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Revised 17.05.2018