Flippin' Lipids - A Study of P4-ATPases

PhD defence, Friday 15 June 2018, Jakob Jensen Ulstrup.

2018.06.15 | Trine Berndt Turtiainen Scheelke

Jakob Jensen Ulstrup

During his Ph.d-studies, Jakob Jensen Ulstrup has done research in the field of P4-ATPase lipid transporters. These transporters are exclusively found in eukaryotic organisms, where they are involved in lipid-based signaling ie. blood coagulation, apoptosis and biogenesis of vesicles. They are part of the P-type ATPase superfamily, which mainly consists of primary transport proteins that “pump” different cations across cellular membranes in a process driven by ATP. These pumps have been extensively studied over the last decades, both with respect to their biochemistry and structural composition. However, the flippases remain among the least understood members of the family, especially with regards to their transport mechanism, which allow them to transport a far larger substrate than a cation. This is one of the central questions asked in this field and is known as “the large substrate problem”. Jakob Jensen Ulstrup has studied the flippases Drs2 and Neo1 from the yeast organism Saccharomyces cerevisiae by employing such methods as macromolecular X-ray crystallography and single-particle electron microscopy. The main goal was to reach a better understanding of their transport mechanism and regulation. He has been part of achieving the first structural insight of a P4-ATPase and its auto-regulation.

The PhD degree was completed at the Department of Molecular Biology and Genetics, Science and Technology, Aarhus University.

This résumé was prepared by the PhD student.

Time: Friday 15 June 2018 at 13.00
Place: Building 3130, room 3.01, Conference room, Department of Molecular Biology and Genetics, Gustav Wieds vej 10c, Aarhus University, 8000 Aarhus C.
Title of PhD thesis: Structural and functional characterization of P4-ATPase lipid flippases
Contact information: Jakob Jensen Ulstrup, e-mail: jakobu@mbg.au.dk, tel.: +45 53379455
Members of the assessment committee:
Professor Todd R. Graham, Department of Cell and Developmental Biology, Vanderbilt University, USA
Professor Thomas Günther-Pomorski, Department of Plant and Environmental Sciences, University of Copenhagen
Professor Ditlev E. Brodersen, Department of Molecular Biology and Genetics, Aarhus University
Main supervisor:
Professor Poul Nissen, MBG, Aarhus University
Dr. Joseph Lyons, MBG, Aarhus University
Language: The PhD thesis will be defended in English

The defence is public.

The PhD thesis is available for reading at the Graduate School of Science and Technology/GSST,
Ny Munkegade 120, building 1520, rooms 128-134, 8000 Aarhus C.

PhD defence
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Revised 18.06.2018