Lipidoid Materials-based Delivery Systems for RNAi Therapeutics

PhD defence, Friday 15 December 2017, Ping Song.

2017.12.15 | Trine Berndt Turtiainen Scheelke

Ping Song

During her PhD studies, Ping Song investigated the therapeutic applications of lipidoid based delivery systems for RNA based drugs. RNA interference (RNAi) is an important mechanism triggered by double-stranded RNA to regulate gene expression. Small interfering RNA (siRNA) and microRNA (miRNA) have attracted great interest due to their potential to specifically downregulate gene expression via RNAi. However, the delivery of these small RNAs is limited by various biological barriers. As a result, it is essential to develop safe and effective delivery systems. In our lab, novel lipidoid materials based delivery systems were developed and showed great potential in siRNAs/miRNAs delivery. Ping Song evaluated the potential applications of these lipidoid materials based nanoscale vehicles to deliver small RNAs and their therapeutic applications.

The PhD degree was completed at the Interdisciplinary Nanoscience Center (iNANO), Science and Technology, Aarhus University.

This résumé is prepared by the PhD student.

Time: Friday, 15 December 2017 at 13.15
Place: Building 1532, room 116, Lecture Theatre G1, Department of Mathematics, Ny Munkegade 118, Aarhus University, 8000 Aarhus C.
Title of dissertation: Therapeutic Applications of Lipidoid Nanoparticles for RNAi-based Delivery
Contact information: Ping Song, e-mail:psong@inano.au.dk, tel.: +45 5028 8480
Members of the assessment committee:
Professor and Director of the Centre for Drug Research Arto Urtti, Centre for Drug Research, Faculty of Pharmacy, University of Helsinki, Finland
Professor Hanne Mørck Nielsen, KU Pharma, Biologics, University of Copenhagen
Professor Duncan Sutherland (chair), iNANO, Aarhus University
Main supervisor:
Professor Jørgen Kjems, iNANO and Department of Molecular Biology and Genetics, Aarhus University
Language: The PhD dissertation will be defended in English

The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST,
Ny Munkegade 120, building 1520, rooms 128-134, 8000 Aarhus C.

PhD defence
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Revised 18.01.2018