Project DETECT – Rapid detection of drugs in solution by DNA displacement

PhD defence, Wednesday, 15 June 2016. Michael Vingborg Kjelstrup.

2016.06.15 | Mette Pultz

Michael Vingborg Kjelstrup

During his PhD studies, Michael Vingborg Kjelstrup has been working on the development of a new method for fast, inexpensive and accurate determination of drugs in blood samples. The ability to determine the presence of certain drugs in blood is of high importance in the therapy of critically ill patients. The method is aimed at providing the doctors with an improved option for personalizing drug dosage from patient to patient. The method is based on binding of small molecules to antibodies, and this binding can be measured with specific DNA sequences. The method is being optimized in performing the detection in less than 30 minutes from sample to result. During Michael Vingborg Kjelstrup’s studies, he took part in the early formation of the method that is currently being further developed for a product ready for commercialization.

The PhD degree was completed at the Interdisciplinary Nanoscience Center (iNANO), Science and Technology, Aarhus University.

This résumé is prepared by the PhD student.

Time: Wednesday, 15 June 2016 at 13.15
Place: Building 1514, room 213, lecture theatre I, Department of Chemistry, Langelandsgade 140, Aarhus University, 8000 Aarhus C.
Title of dissertation: DNA Modification – For Inversion and Sensing
Contact information: Michael Vingborg Kjelstrup, e-mail:, tel.: +45 2972 5653
Members of the assessment committee:
Professor Andriy Mokhir, Department of Chemistry and Pharmacy, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany
Professor Poul Nielsen, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark
Professor Troels Skrydstrup (chair), iNANO and Department of Chemistry, Aarhus University
Main supervisor:
Professor Kurt V. Gothelf, iNANO and Department of Chemistry, Aarhus University
Language: The PhD dissertation will be defended in English

The defense is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1520, rooms 128-134, 8000 Aarhus C.

PhD defence
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Revised 21.09.2017