Protein Kinase D1 and its potential in the treatment of inflammatory bowel diseases

PhD defence, Thursday 12 October 2017, Ditte Søvsø Gundelund Nielsen.

2017.10.12 | Steffi Hjerrild Iversen

Ditte Søvsø Gundelund Nielsen

During her studies, Ditte Søvsø Gundelund Nielsen conducted research on the effect of the enzyme protein kinase D1 (PKD1) in relation to inflammatory bowel diseases that are characterized by wounds and inflammation along the gastrointestinal tract.

Ditte Søvsø Gundelund Nielsen studied how PKD1 affects the wound healing process in intestinal epithelial cells and the immune response in macrophages in vitro. In addition, she investigated whether the lactic acid bacteria, Lactococcus lactis could be used for expression of recombinant PKD1, since this bacterium can be used in intestinal drug delivery of expressed proteins. The new research findings contribute to the understanding on the effect of PKD1 in relation to human intestinal health and the potential of PKD1 in the treatment of inflammatory bowel diseases.

The PhD degree was completed at the Department of Animal Science, Science and Technology, Aarhus University.

This résumé was prepared by the PhD student.

Time: Thursday 12 October 2017 at 9.00.
Place: Meeting room 2, Blichers Allé 20, Aarhus University, Foulum, 8830 Tjele
Title of dissertation: Protein kinase D1 and inflammatory bowel diseases – a study on protein kinase D1 and its influence on the wound healing process and intestinal inflammation in vitro
Contact information: Ditte Søvsø Gundelund Nielsen, e-mail:, tel.: +45 87154259
Members of the assessment committee:
Professor Federica Cheli, Department of Health, Animal Science and Food Safety, University of Milan, Italy
Professor Hanne Frøkiær, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
Senior Scientist Ole Højberg (chair), Department of Animal Science, Aarhus University, Foulum, Denmark
Main supervisor:
Senior Scientist Stig Purup, Department of Animal Science, Aarhus University, Foulum, Denmark
Postdoc Marlene Fredborg, Department of Animal Science, Aarhus University, Foulum, Denmark
Professor Vibeke Andersen, Hospital of Southern Jutland, Aabenraa, Denmark and Institute for Reginal Health Research and Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark
Language: The PhD dissertation will be defended in English

The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST,
Ny Munkegade 120, building 1520, rooms 128-134, 8000 Aarhus C.

PhD defence
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Revised 24.04.2018