SMEPT: A new approach of specialized drug delivery via directed enzyme-prodrug therapy incorporated into polymer matrices.

PhD defence, Friday 17 February 2017. Betina Fejerskov

2017.02.17 | Karen Konradi

Betina Fejerskov

During her studies, Betina Fejerskov investigated the opportunity of directed enzyme-prodrug therapy as a novel drug delivery system with the introduction to polymer matrices. Thus, a bioactive enzyme was incorporated into polymer matrices allowing the conversion of a benign prodrug into its active agent through the diffusive network. This approach was termed Substrate Mediated Enzyme Prodrug Therapy (SMEPT), and for success as a drug delivery system, the research focused on the methods of control over drug dosage as well as the local generation of diverse therapeutic agents. To this end, Betina Fejerskov studied the delivery of the pleiotropic and transient messenger molecule nitric oxide.

Based on the findings, SMEPT is believed to improve the options for specialized and personalized treatment of various diseases.

The PhD degree was completed at the Graduate School of Science and Technology, Aarhus University.

This resumé was prepared by the PhD student.


Time: Friday 17 February 2017, at 1 PM.

Place: Lecture Theatre 1, Department of Chemistry, Building 1514, room 213, Aarhus University, Langelandsgade 140, 8000 Aarhus C.

Title of dissertation: Substrate Mediated Enzyme Prodrug Therapy – for localized synthesis and delivery of therapeutic agents.

Contact information: Betina Fejerskov, e-mail:, tel.: + 45 3069 1234.

Members of the assessment committee:

Professor Jürgen Groll, Department for functional materials in medicine and dentistry, University of Würzburg.

Dr. Fouzia Boulmedais, Institut Charles Sadron, CNRS.

Associate Professor Henrik Birkedal (chair), Department of Chemistry,  Aarhus University.

Main supervisor: Associate Professor Alexander N. Zelikin, Department of Chemistry, Aarhus University.

Language: The PhD dissertation will be defended in English.


The defense is public.

The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1520, rooms 128-134, 8000 Aarhus C.

PhD defence
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Revised 17.05.2018