Transitional self-assembly of biomolecules – Scanning probe microscopy studies

PhD defence, Friday, 3 June 2016. Hüsnü Aslan.

2016.06.03 | Mette Pultz

Hüsnü Aslan

An atomic force microscopy image showing templated self-assembly of biomolecules-in yellow (bovine serum albumin proteins) into a triangular shape inside and outside the self-assembled triangular DNA frame-in orange.

Self-assembly is an autonomous action, which results in ordered formation of its building blocks at all scales in nature – from the formation of atomic crystals to galaxies. During his PhD studies, Hüsnü Aslan researched the molecular self-assembly (MSA) phenomenon. Employing state-of-the-art microscopy techniques, Hüsnü Aslan monitored and manipulated a variety of biological building blocks at single-molecular level to understand how they form structures. He was particularly interested in what he thinks is the most relevant to the existence of human kind, the MSA of life’s seed – DNA. In a set of projects, he investigated the dynamics of different biomolecular interactions using DNA as a nanoconstruction material, to reveal their scientific correlation and to transfer these values to technological applications.

The new research findings contribute to the understanding of the molecular self-assembly phenomenon. To this end, Hüsnü Aslan developed a new method for multidimensional biomolecule patterning with nanoprecision in practically any shape, following the co-development of a method for directed polymerization on a fully addressable, two-dimensional DNA nanosheet.

The PhD degree was completed at the Interdisciplinary Nanoscience Center (iNANO), Science and Technology, Aarhus University.

This résumé was prepared by the Ph.D. student.

Time: Friday, 3 June 2016 at 13.15
Place: Building 1593, Room 012, the Lecture Theatre, iNANO House, Gustav Wieds Vej 14, Aarhus University, 8000 Aarhus C.
Title of dissertation: Investigation of DNA self-assembly at nanoscale
Contact information: Hüsnü Aslan, e-mail: aslan@inano.au.dk, tel.: +45 2916 6342
Members of the assessment committee:
Associate Professor Yonggang Ke, Wallace H. Coulter Department of Biomedical Engineering, Georgia Tech and Emory University, USA
Professor Ricardo Garcia, Instituto de Ciencia de Materiales de Madrid, CSIC, Spain
Associate Professor Liv Hornekær (chair), iNANO and Department of Physics and Astronomy, Aarhus University
Main supervisor:
Associate Professor Mingdong Dong, iNANO, Aarhus University
Co-supervisor:
Professor Flemming Besenbacher, iNANO, Aarhus University
Language: The PhD dissertation will be defended in English

The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1520, rooms 128-134, 8000 Aarhus C.

PhD defence
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Revised 21.09.2017