Usability of cytotoxic protein-fat complexes

PhD defence, Friday, 26 January 2018. Henriette Kristina Søster Frislev

2018.01.26 | Rikke J. Ljungmann

Henriette Kristina Søster Frislev

During her PhD studies, Henriette Frislev has investigated a family of complexes, composed of protein and fatty acid from milk. The hypothesis was that these complexes were a potential candidate for cancer therapy. However, Henriette Frislev observed a lack of stability in environments simulating the circulatory system and unfortunately a lack of cancer cell selective. This is caused by the nonselective delivery of the cytotoxic fatty acid component to the cell membrane.

By replacing the fatty acid component, complexes with significantly reduced cytotoxicity can be formed. These complexes were shown to have the potential as 1) a delivery and encapsulation system to fortify food with vitamin D to protect against vitamin D deficiency and 2) a delivery system of cholesterol to cells, in order to study the effect of high cholesterol level. Improvement of the stability of protein-fatty acid complexes is needed in the future to make these complexes more useful.

The PhD degree was completed at the Interdisciplinary Nanoscience Center (iNANO), Science and Technology, Aarhus University.

This résumé was prepared by the PhD student.

Time: Friday, 26 January 2018 at 13.15
Place: Building 1593, room 012, the Lecture Theatre, iNANO House, Gustav Wieds vej 14, Aarhus University, 8000 Aarhus C.
Title of dissertation: Exploring the potential of liprotides as a delivery and encapsulation system
Contact information: Henriette Frislev, e-mail: hsfrislev@inano.au.dk, tel.: +45 2346 7514
Members of the assessment committee:
Professor Øyvind Halskau, Department of Molecular Biology, University of Bergen, Norway
Professor Jakob Rahr Winther, Department of Biology, University of Copenhagen
Associate Professor Ken Howard (chair), iNANO, Aarhus University
Main supervisor:
Professor Daniel Otzen, iNANO and Department of Molecular Biology and Genetics, Aarhus University
Language: The PhD dissertation will be defended in English

The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1520, rooms 128-134, 8000 Aarhus C.

PhD defence
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Revised 25.04.2018